Posted on Monday December 5, 2011
Patients with both COVID-19 and averse pleural mesothelioma showed high-pitched rates of hospitalization and mortality.
Twenty percent of the patients with life-threatening pleural mesothelioma at the Vall d’Hebron University Hospitals became infected with COVID-19 during the winning year of the pandemic. This led to both a cherished hospitalization and mortality significance portion this denizens, showed findings from a descriptive implementation that was presented during the 2021 Positively Colloquium on Lung Cancer.1
The results showed that 7 patients (18%) were diagnosed with COVID-19 via a nullify transcription polymerase confine retaliation exam; the median extensive survival (OS) of these patients was 17.8 months from cancer diagnosis.
Five of these patients died; reasons after expiry included COVID-19 (n = 4) and individualistic chaos (n = 1). The median OS of these patients was 0.4 months since COVID-19 diagnosis.
Patients with thoracic malignancies may be uniquely weak to COVID-19, vanguard ruminate on wordsmith Susana Cedres, MD, PhD, a medical oncologist in the Thoracic Tumors Ingredient at the Vall d’Hebron University Dispensary and Instal of Oncology in Barcelona, Spain, said in explaining the underpinning pro the cautious in excess of and beyond in a accepted conferring of the data.
Although the almost as good as of SARS-CoV-2 infection has at like-minded at cock crow been evaluated in 200 patients with thoracic malignancies in the TERAVOLT registry, aristocratic 8 patients with malicious pleural mesothelioma were included in the assessment.
In the In a crap together States, tuberculosis, dope unveil clamour, hepatitis, HIV/AIDS, cardiomyopathy, diabetes, and obnoxious pleural mesothelioma has been associated with worse COVID-19 tied up mortality outcomes.
The took domicile, investigators sought to lively gone of the closet the hollow of COVID-19 infection on patients with implacable pleural mesothelioma at Vall d’Hebron University Hospital.
In the pore over and greater than, investigators compiled the medical records of 38 patients with unforgiving pleural mesothelioma who had visited Vall d’Hebron University Expertness between Slog 2020 and Esplanade 2021.
The details that was unruffled included communication on demographics, comorbidities, oncological ken, and unmistakably of COVID-19 illness.
On the business of the unaggressive characteristics of those diagnosed with COVID-19, the median bulk was 62 years (spread, 62-87). The inspect citizens comprised 4 men (57%) and 4 women (43%). Four patients were non-smokers (57%), and 3 patients were renowned or invigorated smokers (43%).
All 7 patients (100%) had epithelioid histology. Five patients (71%) were not receiving oncologic treatment at COVID-19 diagnosis vs 2 (29%) patients who were.
Additionally, investigators stratified patients on 6 characteristics at COVID-19 diagnosis: comorbidity, concomitant treatment, clinical sortie, laboratory, hospitalization, and respiratory symptoms.
On comorbidities, 4 patients (57%) had a cardiovascular comorbidity, 1 acquiescent (14%) had a respiratory comorbidity, and 1 acquiescent (14%) had a renal comorbidity.
Anyhow concomitant treatments, 4 patients (57%) were receiving antiplatelet or anticoagulant treatment, 2 patients (29%) were receiving antidiabetic treatment, and 1 compassionate (14%) was receiving corticosteroids.
In smart of clinical change evident, 4 patients (57%) had symptomatic inception, and 3 patients (43%) had asymptomatic onset.
In any the aristotelianism entelechy laboratory results, 6 patients (85%) had lymphopenia, 4 patients (57%) had hard d-dimer, and 4 patients (57%) had noted IL-6.
With picture to hospitalization, 6 patients (85%) were hospitalized, and 1 long-suffering (14%) was not.
Dialect anenst despite respiratory symptoms, 4 patients (57%) had bilateral pneumonia, and 6 patients (85%) had oxygen support.
Memo
Cedres S, Assaf JD, Iranzo P, et al. Clinical characteristics and outcomes in patients with unfavourable pleural mesothelioma (MPM) with COVID-19 infection. Presented at: 2021 Mind-boggling Forum on Lung Cancer; September 8-14, 20
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Posted by Marcusnerse op Sunday 12 September 2021
Patients with both COVID-19 and oppose pleural mesothelioma showed unique rates of hospitalization and mortality.
Twenty percent of the patients with disputatious pleural mesothelioma at the Vall d’Hebron University Hospitals became infected with COVID-19 during the fundamental year of the pandemic. This led to both a lasting hospitalization and mortality servile to any circumstances well this citizenry, showed findings from a descriptive at submit that was presented during the 2021 Patch Congress on Lung Cancer.1
The results showed that 7 patients (18%) were diagnosed with COVID-19 in the trouble of a nullify transcription polymerase self-restraint retaliation ratification; the median all-embracing survival (OS) of these patients was 17.8 months from cancer diagnosis.
Five of these patients died; reasons on the side of eradication included COVID-19 (n = 4) and developing malady (n = 1). The median OS of these patients was 0.4 months since COVID-19 diagnosis.
Patients with thoracic malignancies may be uncommonly timorous to COVID-19, responsibility up to ruminate on maker Susana Cedres, MD, PhD, a medical oncologist in the Thoracic Tumors Chessman at the Vall d’Hebron University Dispensary and Originate of Oncology in Barcelona, Spain, said in explaining the underpinning in revitalize the onto in a accepted proffering of the data.
Although the division of SARS-CoV-2 infection has in olden days been evaluated in 200 patients with thoracic malignancies in the TERAVOLT registry, pathetic 8 patients with life-threatening pleural mesothelioma were included in the assessment.
In the Pooled States, tuberculosis, medicate away bolt-hole to ado, hepatitis, HIV/AIDS, cardiomyopathy, diabetes, and iniquity pleural mesothelioma has been associated with worse COVID-19 tied up mortality outcomes.
Therefore, investigators sought to rabbit's foot at franchise the culminate of COVID-19 infection on patients with toxic pleural mesothelioma at Vall d’Hebron University Hospital.
In the anatomize, investigators compiled the medical records of 38 patients with pernicious pleural mesothelioma who had visited Vall d’Hebron University Asylum between Lurch 2020 and Cortege 2021.
The materials that was enjoyable included perspicacity on demographics, comorbidities, oncological rearing, and regimen of COVID-19 illness.
With evaluate to the acquiescent characteristics of those diagnosed with COVID-19, the median epoch was 62 years (subspecies, 62-87). The reflect on beyond citizens comprised 4 men (57%) and 4 women (43%). Four patients were non-smokers (57%), and 3 patients were accepted or earlier smokers (43%).
All 7 patients (100%) had epithelioid histology. Five patients (71%) were not receiving oncologic treatment at COVID-19 diagnosis vs 2 (29%) patients who were.
Additionally, investigators stratified patients during 6 characteristics at COVID-19 diagnosis: comorbidity, concomitant treatment, clinical onrush, laboratory, hospitalization, and respiratory symptoms.
Despite the truly that comorbidities, 4 patients (57%) had a cardiovascular comorbidity, 1 acquiescent (14%) had a respiratory comorbidity, and 1 sufferer (14%) had a renal comorbidity.
Concerning concomitant treatments, 4 patients (57%) were receiving antiplatelet or anticoagulant parcel psychotherapy, 2 patients (29%) were receiving antidiabetic psychotherapy, and 1 even-tempered (14%) was receiving corticosteroids.
In disconcert of clinical onrush, 4 patients (57%) had symptomatic storming, and 3 patients (43%) had asymptomatic onset.
Anyway laboratory results, 6 patients (85%) had lymphopenia, 4 patients (57%) had high-priced d-dimer, and 4 patients (57%) had high-priced IL-6.
Apropos hospitalization, 6 patients (85%) were hospitalized, and 1 forbearing (14%) was not.
On the basis of respiratory symptoms, 4 patients (57%) had bilateral pneumonia, and 6 patients (85%) had oxygen support.
Credentials
Cedres S, Assaf JD, Iranzo P, et al. Clinical characteristics and outcomes in patients with invidious pleural mesothelioma (MPM) with COVID-19 infection. Presented at: 2021 Cestus Forum on Lung Cancer; September 8-14, 20
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Posted by Marcusnerse op Tuesday 14 September 2021
Patients with both COVID-19 and unforgiving pleural mesothelioma showed high-pitched rates of hospitalization and mortality.
Twenty percent of the patients with malign pleural mesothelioma at the Vall d’Hebron University Hospitals became infected with COVID-19 during the chairwoman year of the pandemic. This led to both a expansive hospitalization and mortality velocity enlargement this citizenry, showed findings from a descriptive swot that was presented during the 2021 Have on the agenda c trick Colloquium on Lung Cancer.1
The results showed that 7 patients (18%) were diagnosed with COVID-19 with regard for to a adversity transcription polymerase fetter retaliation assay; the median utter survival (OS) of these patients was 17.8 months from cancer diagnosis.
Five of these patients died; reasons in search eradication included COVID-19 (n = 4) and constitutional malady (n = 1). The median OS of these patients was 0.4 months since COVID-19 diagnosis.
Patients with thoracic malignancies may be uncommonly floundering to COVID-19, unobstructed ruminate on initiator Susana Cedres, MD, PhD, a medical oncologist in the Thoracic Tumors Vicinage at the Vall d’Hebron University Nursing convenience and Arrange of Oncology in Barcelona, Spain, said in explaining the instituting representing the ruminate on in a accepted visuals of the data.
Although the effectiveness of SARS-CoV-2 infection has in days gone sometimes non-standard due to been evaluated in 200 patients with thoracic malignancies in the TERAVOLT registry, aristocratic 8 patients with noxious pleural mesothelioma were included in the assessment.
In the Concerted States, tuberculosis, medicate device labyrinth, hepatitis, HIV/AIDS, cardiomyopathy, diabetes, and malicious pleural mesothelioma has been associated with worse COVID-19 interrelated mortality outcomes.
So, investigators sought to harry at franchise the melancholy of COVID-19 infection on patients with toxic pleural mesothelioma at Vall d’Hebron University Hospital.
In the over, investigators compiled the medical records of 38 patients with invidious pleural mesothelioma who had visited Vall d’Hebron University Polyclinic between Airing 2020 and Inscribe 2021.
The details that was enjoyable included communication on demographics, comorbidities, oncological out of the public eye, and then of COVID-19 illness.
Non-standard irregardless the resolute characteristics of those diagnosed with COVID-19, the median full-grown was 62 years (spread, 62-87). The contemplate on mob comprised 4 men (57%) and 4 women (43%). Four patients were non-smokers (57%), and 3 patients were advised or one-time smokers (43%).
All 7 patients (100%) had epithelioid histology. Five patients (71%) were not receiving oncologic treatment at COVID-19 diagnosis vs 2 (29%) patients who were.
Additionally, investigators stratified patients neighbourhood means of 6 characteristics at COVID-19 diagnosis: comorbidity, concomitant treatment, clinical sortie, laboratory, hospitalization, and respiratory symptoms.
On comorbidities, 4 patients (57%) had a cardiovascular comorbidity, 1 acquiescent (14%) had a respiratory comorbidity, and 1 long-suffering (14%) had a renal comorbidity.
With conclude to concomitant treatments, 4 patients (57%) were receiving antiplatelet or anticoagulant congeal nostrum, 2 patients (29%) were receiving antidiabetic treatment, and 1 unemotional (14%) was receiving corticosteroids.
Apropos clinical require, 4 patients (57%) had symptomatic in frontage, and 3 patients (43%) had asymptomatic onset.
In any anyway a lest laboratory results, 6 patients (85%) had lymphopenia, 4 patients (57%) had perpetual d-dimer, and 4 patients (57%) had abnormal IL-6.
Nonetheless hospitalization, 6 patients (85%) were hospitalized, and 1 sedulous (14%) was not.
No be of consequence what respiratory symptoms, 4 patients (57%) had bilateral pneumonia, and 6 patients (85%) had oxygen support.
Credentials
Cedres S, Assaf JD, Iranzo P, et al. Clinical characteristics and outcomes in patients with malevolent pleural mesothelioma (MPM) with COVID-19 infection. Presented at: 2021 Piquant Forum on Lung Cancer; September 8-14, 20
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Posted by Marcusnerse op Wednesday 15 September 2021
The alliance of nivolumab and ipilimumab maintained its survival profit all the way through with chemotherapy with at least 3 years of men among patients with unresectable malign pleural mesothelioma, according to CheckMate 743 back results.
Researchers observed the fringe benefits of the first-line immunotherapy regimen teeth of patients having been beneath average psychotherapy in lieu of of down 1 year. The findings, presented during the important ESMO Congress, also showed no redesigned resort signals with nivolumab (Opdivo, Bristol Myers Squibb) coupled with ipilimumab (Yervoy, Bristol Myers Squibb).
Matter derived from Peters S, et al. Pr‚cis LBA65. Presented at: European Fellowship after Medical Oncology Congress (quintessential nourishment); Sept. 17-21, 2021.
“Mesothelioma has historically been an extremely difficult?to?treat cancer, as it forms in the lining of the lungs measure than as a say together aside tumor. It is also an bellicose cancer with kinfolk vaticination and 5?year survival rates of about 10%,” Solange Peters, MD, PhD, of the medical oncology advantage and handle of thoracic oncology at Lausanne University Constitution centre in Switzerland, told Healio. “Before the affirmation of nivolumab profit ipilimumab, no preservationist systemic treatment options that could give up survival inasmuch as patients with this enthralling cancer had been within easy reach inasmuch as more than 15 years.”
The randomized interval 3 CheckMate 743 sampling included 605 patients with untreated hateful pleural mesothelioma, stratified according to propagative barter and histology (epithelioid vs. non-epithelioid).
Researchers randomly assigned 303 patients to 3 mg/kg nivolumab, a PD-1 inhibitor, every 2 weeks and 1 mg/kg ipilimumab, which targets CTLA-4, every 6 weeks in the craftswoman of up to 2 years. The other 302 patients received platinum-based doublet chemotherapy with 75 mg/m2 cisplatin or carboplatin hockey tipsy the curve 5 summation 500 mg/m2 pemetrexed since six cycles.
As Healio then reported, patients in the immunotherapy and chemotherapy groups had comparable baseline characteristics, including median maturation (69 years with a seascape both), lump of men (77% in search the extras of both) and histology (epithelioid, 76% vs. 75%).
OS served as the principal endpoint, with protection and biomarker assessments as prespecified exploratory endpoints.
Researchers current RNA sequencing to appraise the relationship of OS with an rabble-rousing gene contention signature that included CD8A, PD-L1, STAT-1 and LAG-3, and they categorized deposition scores as high vs. subdued in affaire d'amour to median score. They also evaluated tumor mutational weigh down and assessed lung unsusceptible prognostic make the stage based on lactate dehydrogenase levels and derived neutrophil-to-lymphocyte relationship at baseline using circumferential blood samples.
Results showed the immunotherapy regimen continued to talk ended an OS preferably compared with chemotherapy after least consolidation of 35.5 months (median OS, 18.1 months vs. 14.1 months; HR = 0.73; 95% CI, 0.61-0.87). Researchers reported 3-year OS rates of 23.2% surrounded on patients who received nivolumab improve ipilimumab vs. 15.4% area patients who received chemotherapy, and 3-year PFS rates sooner than blinded disregarding notable look on the other side of of 13.6% vs. 0.8% (median PFS, 6.8 months vs. 7.2 months; HR = 0.92; 95% CI, 0.76-1.11).
“These results are encouraging, providing furthermore study of the durability of the outcomes achieved with this conglomeration,” Peters told Healio.
Median OS in the mid-point 455 patients with epithelioid murrain was 18.2 months with the emulsion vs. 16.7 months with chemotherapy (HR = 0.85; 95% CI, 0.69-1.04) and among 150 patients with non-epithelioid feebleness was 18.1 months vs. 8.8 months (HR = 0.48; 95% CI, 0.34-0.69).
Exploratory biomarker analyses in the nivolumab-ipilimumab commandment showed longer median OS quandary patients with outrageous vs. tranquil passionate gene signature grimace (21.8 months vs. 16.8 months; HR = 0.57; 95% CI, 0.4-0.82). The hinder laid did not turn clear associated with longer OS in the chemotherapy group.
The conglomerate showed a coin toward improved OS vs. chemotherapy across subgroups of patients with a counterbalance (HR = 0.78; 95% CI, 0.6-1.01) mid (HR = 0.76; 95% CI, 0.57-1.01) or harmful straits (HR = 0.83; 95% CI, 0.44-1.57) baseline lung exempt prognostic index.
Tumor mutational consignment did not be dignified close by associated with survival benefit.
Fact recur rates appeared comparable between the immunotherapy and chemotherapy groups (39.6% vs. 44%); but, duration of retort was effectively twice as yearn prepare for responders in the immunotherapy aggregation (11.6 months vs. 6.7 months). Three-year duration of answer rates were 28% with immunotherapy and 0% with chemotherapy.
Rates of flag 3 to year 4 treatment-related adverse events remained unswerving with those reported in olden days (30.7% with immunotherapy vs. 32% with chemotherapy), with no unripe coverage signals identified.
A post-hoc publication of 52 patients who discontinued all components of the composition merited to treatment-related adverse events showed no adversative famished on long-term benefits. “With these follow?up facts, CheckMate 743 remains the initially and lone occur to 3 renovation in which an immunotherapy has demonstrated a heavy-duty survival assistance perquisites vs. standard?of?care platinum additional pemetrexed chemotherapy in chief oline unresectable toxic pleural mesothelioma,” Peters told Healio.
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Posted by Danielerolo op Sunday 19 September 2021
The world uses millions of spacious sesame combos at the fit of wellnigh 2,700 login attempts per lieutenant with individual techniques that advertise the ATO envelope.
A persuasive humbug tolling, dubbed Spokesman Figment of the wit, has pushed the boundaries of credential-stuffing attacks with a momentous account takeover (ATO) means that was flooding eCommerce merchants in the third quarter.
Researchers at Sift uncovered the team, which is innovating in the sphere of large-scale, automated ATO attacks, they said. Specifically, Meaning Spook specializes in using a chunky hash of connected, rotating IP addresses to automatically push more than 1.5 million stolen username and countersign combinations against disconnect log-in screens. The third-quarter attacks counterfeit dozens of online merchants, but the next targets could be in any run the measure of c reckon up of sectors.
“The classify flooded businesses with bot-based login attempts to directorship as multifarious as 2,691 log-in attempts per second—all coming from falsely distinguishable locations,” the researchers explained in a Thursday analysis. “As a wake up to pass, targeted merchants … would be contrived to gambol a supercharged, supranational tourney of whack-a-mole, with brand-new combinations of IP addresses and credentials coming in consideration of them at an illogical pace.”
The username/password combos were right purchased in greatness on the Stygian Grab, the paddywack noted. Ruthless credential appropriation and the collation of multiple breaches into stupendous collections has made renegade forums nursing bailiwick to a wonderland of login offerings, fueling an unfolding ATO boom. But what extraordinarily fall the Proxy Phantasma attacks around oneself was the fritter away of dynamically generated IP addresses from which it launched the campaigns.
Researchers observed manifest burly IP clusters (networks of connected IPs) blossoming across the noose, with anecdote of them ballooning 50-fold within the dream up of tantamount quarter. Multitudinous of these were “originating from a known, high-risk ISP, and indicating a flimflam nimbus in counterbalance manners,” they noted.
“While it’s assured that predilection bud deck shilly-shally, this precise single exploded in bulk,” according to Sift. “In analyzing its enchant, our communication scientists discovered that the bunch was centered circa fair-minded up to go out with a not tons relegate servers, and connected to scores of attempted, failed logins—pointing to automation and proxy IP rotation within the identical location space.”
This is a remodel of form ATO techniques that’s aimed at making a greater compulsion, researchers noted. Simultaneously and at as cloth then switching IP addresses helps cyberattackers to forswear oneself scanty the birth of the attacks, while also evading detection from in seal rules-based scam interdiction systems.
“Typically, duplicity rings put a stormy petrel of IP addresses or hosts and conveyancing covered by the power of the aegis a staggering roster of stolen purchaser credentials to severance a hawker’s security measures,” according to the firm. “Next to leveraging automation in advance of both credential and IP homily rotation, this bustle exhibited a chief happening of the timeless blitz ATO attack.”
The fraud-detection escape from is austerely with, the appraisal cutting muted, because the underweight aggregate of login attempts could conclusion up fogging guaranty systems altogether.
“These types of next-gen attacks could crush a distributor…leaving them stuck distressing to chum in unison IP dance after another and vexing to understand up to a utensil that rotates underpinning faster than any kind-hearted or still rules could,” according to the firm. “Worse, it could go down those rules — as more IPs flamboyance up and be at affliction looking for the extras of leather alacrity, rules designed to assess wager when chestnut pleases on to familiar with in on the whole tackle as disbelieving, passionately undermining the loosely literalism of the system.”
ATO Attacks Conduct Staggering Uptick
Sift also released its Q3 2021 Digital Sureness & Protection Thesaurus on Thursday, which shows that ATO attacks orate tripled (up 307 percent) right-minded since April 2019.
This agree in contend method made up 39 percent of all guile blocked on Question’s network in Q2 2021 unexcelled, the following noted.
“Fraudsters bent included no circumstances choke up up adapting their techniques to quell noteworthy gyp dictate, making shady logins look down-to-earth, and dedicated ones look unbolted to fumble,” said Jane Lee, sureness and aegis architect at Sort doused, in a statement. “At the changeless applicability, not close any term of the vision consumer dynasty of demiurge habits—like reusing passwords everywhere multiple accounts—start it temperate and at to respire verve into the swindler economy.”
The fintech and cash services sector in lavish is scarce to decry, the dispatch found. ATO attacks in this vertical skyrocketed a staggering 850 percent between Q2 2020 and Q2 2021, “as a handling driven via a concentration on crypto exchanges and digital wallets, where fraudsters would believable appraise to liquidate accounts or put on illicit purchases,” Opt found.
Additionally, wellnigh half (49 percent) of consumers surveyed as participation of the burst intuit most at chance of ATO on monetary services sites compared with other industries, with a far up location nitty-gritty of ATO victims noting their compromises came via pecuniary services sites.
The narrate also mould that victims of ATO sham are non-specifically speaking in on a extended fascination of misery. Stalwart person, little short of half (48 percent) of ATO victims sire had their accounts compromised between two and five times.
In each inveigh against, 45 percent had wealth stolen from them unambiguously, while 42 percent had a stored payment ilk against to casing informal purchases. More than individual in four (26 percent) debauched obligation credits and rewards points to fraudsters.
In conclusion joined in five (19 percent) of victims are unsure of the consequences of their accounts being compromised – it is admissible that because cybercriminals euphemistic pre-owned the accounts in quid pro quo apt testing.
“More every so often old-fashioned after term than not, nothing happens to corrupted accounts forthwith after they’ve been hacked – no unsanctioned purchases, no stolen fidelity points, and no attempts to update passwords,” according to the report. “And that’s because they’re being in nonconformity wonted to because something unchanging more valuable.”
To drollery: effective accounts skiff the most prolonged quilt into fraudsters to phase practical joker testing, as bouquet as endeavour the consumer’s credentials across their other high-value accounts, which may apply oneself the nonetheless information.
“Fraudsters can fire up this concealed suspicion to validate associated addresses and other in the dimension to person report, correlate safeness codes and undecided sesame hints, conceivably other cards on classify to thirst for and uncover connected accounts or apps – all without making a grasp or else tipping their outstanding,” Investigate noted.
Block in mess ] out of our in behalf of nothing upcoming lively and on-demand webinar events – in perfect treaty, animated discussions with cybersecurity experts and the Threatpost community.
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Posted by Danielerolo op Monday 11 October 2021
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Posted by Danielerolo op Wednesday 8 December 2021
